Research use only. All products are supplied strictly for laboratory research purposes — not for human or veterinary consumption.

KLOW 80mg Research Blend

KLOW is a four-component research blend: the three peptides in GLOW, with KPV added. It is supplied for laboratory research use only, and each component is described separately below.

Specification

  • Presentation: 80mg — GHK-Cu 50mg + BPC-157 10mg + TB-500 10mg + KPV 10mg
  • Price: £130
  • Evidence status: Predominantly preclinical; no clinical trials of the combination

Components

  • GHK-Cu 50mg — Copper-binding tripeptide studied in dermal matrix and collagen research.
  • BPC-157 10mg — Pentadecapeptide derived from a sequence identified in gastric juice.
  • TB-500 10mg — Synthetic fragment corresponding to the actin-binding region of thymosin β4.
  • KPV 10mg — C-terminal tripeptide of α-melanocyte stimulating hormone.

Research background

KLOW takes the GLOW combination — GHK-Cu, BPC-157 and TB-500 — and adds 10mg of KPV, a tripeptide corresponding to the C-terminal fragment of α-melanocyte stimulating hormone. The amounts of the other three components are unchanged.

KPV is of interest in preclinical inflammation research, particularly in gastrointestinal models, where it has been studied as a fragment that retains some activity of the parent hormone without its pigmentary effects.

As with GLOW, the combination itself has not been studied under controlled conditions. The component literature should not be read as evidence about the blend.

Pathways under investigation

KPV and α-MSH fragment signalling

KPV (lysine-proline-valine) is the C-terminal tripeptide of α-MSH. Preclinical work has examined its effects on inflammatory signalling pathways in cell and rodent models, with particular attention to intestinal epithelium. Unlike the full α-MSH sequence, it is not associated with melanocortin-driven pigmentation.

GHK-Cu and the copper-binding tripeptide pathway

GHK binds copper(II) with high affinity and is studied in relation to extracellular matrix components and copper transport, largely in cell culture and topical formulation research.

BPC-157 and TB-500

Both are studied in preclinical tissue models — BPC-157 in angiogenic signalling and cell migration, TB-500 in actin polymerisation and cell motility. Neither has human efficacy data.

Research and regulatory status

  • None of the four components holds a marketing authorisation as a medicine in the United Kingdom.
  • BPC-157 and TB-500 appear on the World Anti-Doping Agency prohibited list.
  • KPV research is preclinical. No clinical trial has established efficacy in humans for any indication.
  • The combination has not been evaluated in controlled clinical study. Supplied for in-vitro laboratory research only.

Analytical testing and certificates of analysis

Batch documentation for KLOW is available on request where we hold it. We do not publish a public batch database, and no purity, identity, sterility or manufacturing claim is stated anywhere on this site unless documentation for that exact batch supports it. To ask what is held for a particular lot, contact us.

References and further reading

These are starting points for your own reading, not endorsements of any conclusion.

Frequently asked questions

What is the difference between KLOW and GLOW?

KLOW is GLOW with KPV 10mg added — 80mg total rather than 70mg. The GHK-Cu, BPC-157 and TB-500 amounts are identical across both.

What is KPV?

KPV is the C-terminal tripeptide of α-melanocyte stimulating hormone, made up of lysine, proline and valine. It is studied in preclinical inflammation research.

Does KPV cause pigmentation like other α-MSH fragments?

KPV is not associated with the melanocortin receptor-driven pigmentation seen with full α-MSH analogues. It is a different fragment with a different research profile.

Has the four-peptide combination been tested clinically?

No. There are no controlled clinical trials of this combination, and we make no claim about it beyond describing its components.

Related research

Related compounds

Research use only

This product is supplied strictly for in-vitro laboratory research. It is not a medicine, is not licensed by the MHRA, and is not for human or veterinary consumption or administration. We do not supply dosing, reconstitution or administration guidance, and nothing on this page is a therapeutic claim.